Vol. 9, Special Issue 3 (2024)

Author(s): Kannan Kandasamy, Sakthi Karthikeyan, Abul Hassan Ahmad, Hemant Kumar Pandey, Ajay Kumar and A Elamaran

Abstract: The study was conducted to assess the ameliorating potential of Panax ginseng against cold-restraint stress in rats. Cold-restraint stress was induced by keeping the rats at 4 °C for 2 hours from 21^st day to 28^th day of the study. Oxidative parameters in RBC and tissues of liver and kidney were recorded in rats. Rats exposed to cold-restraint stress showed a significant elevation in lipid peroxidation (LPO) in RBC, liver and kidney. The GSH level and SOD activity in RBC, liver and kidney were reduced significantly. The rats treated with Panax ginseng root extract along with stress showed a significant decrease in LPO in RBC, liver and kidney compared to rats treated with stress alone. The GSH level and SOD activity of liver, kidney and RBC was found to be elevated. These observations suggest the protective role of Panax ginseng against cold-restraint stress in rats.