Vol. 8, Special Issue 5 (2023)

Author(s): C Vinaya Sree, Swathi Bommu, Kala Kumar B and Ashok Kumar D

Abstract: L-Homoarginine (hArg) is a non-essential cationic amino acid that is synthesised from its arginine by transamination or by means of lysine catabolism involving the enzymes of ornithine transcarbamoylase (OTC), an enzyme from the urea cycle or the arginine: glycine amidinotransferase (AGAT), an enzyme from the creatine biosynthesis pathway. These enzymes are tissue-specific, hence they synthesised L-hArg in animals and human organs such as the liver, kidneys, brains, and the small intestines. L-hArg plays some important roles in the pathophysiological conditions, endothelial functions, and the energy metabolic processes in different organs. However, the applications of the L-hArg in both human and animal studies is in its juvenile stage, and the mechanism of action in this vital amino acid is not fully substantiated and requires more research attention. Hence, we review the evidence with the perspective of the LhArg usage in the monogastric and human nutrition and its related health implications.