Vol. 9, Issue 3, Part C (2024)

The group III, IV and V rats treated orally with metformin @ 100 mg/kg body weight, Guar gum @ 10 gm/100 gm and combination of Guar gum @ 10 gm/100 gm of feed and metformin @ 100 mg/Kg body weight respectively. There was significant increase in the blood glucose level, serum triglyceride, serum cholesterol, serum LDL, serum AST and serum ALT level values in the treatment groups on 0^th day and were significantly reduced from 14 days onward and on 28^th day it was come down to normal level in the group treatment with Guar gum @ 10 gm/100 gm of feed. Grossly liver and pancreas did not showed any noticeable visual change in any of the experimental rats. No significant change in weights of liver and pancreas in treatment groups. The histopathological changes were predominantly noted in liver and pancreas suggesting induction of diabetes in group II animals. However, restoration of histoarchitecture of these organs was observed after the treatment in these groups.